Selective Intracranial Endovascular Chemotherapy: Alternative Treatment for Adults Diagnosed with Glioma

Abstract

Introduction: Minimally invasive intra-arterial (IA) drug administration is an innovative treatment strategy for patients with brain neoplasms that are difficult to manage and access.Methods: An exhaustive literature search was conducted in two databases (PubMed, Scopus) using MeSH terms "selective intra-arterial cerebral infusion," "endovascular chemotherapy," "glioma," and "glioblastoma." Thirty-five articles on selective endovascular infusion of chemotherapeutic agents for glioma treatment were identified.Results: The use of intra-arterial (IA) drugs has been described since 1950 with remarkable results for modern medicine, which requires disrupting the blood-brain barrier through various strategies to facilitate the distribution of biological or chemotherapeutic agents to brain tissue, including Bevacizumab in monotherapy or combined therapy.Conclusions: Minimally invasive therapeutic strategies offer significant benefits for patients with high-grade tumor lesions, particularly in cases of glioblastoma multiforme (GBM), minimizing complications and limited survival rates.